A research team from the Center for Virology at the University of Nebraska at Lincoln (UNL) has developed experimental multi-vaccines that can protect the body for life from the flu. An unusual vaccine contains the genome of the 4 most common influenza strains. The experiment was conducted on mice infected with nine variants of the flu. The group of mice that received the standard vaccination, after exposure to lethal doses of viruses, became completely ill. The second group received a new vaccine in the usual volume. Seven out of nine varieties of mouse flu survived and survived. The third group received an increased dose of the multivirus vaccine – not one of the mice was even infected. The difficulties in creating a long-term vaccine against influenza are associated with a rapid mutation of viruses and a long incubation period in carriers. Standard methods for creating a vaccine involve the use of weakened or dead viruses that produce immunity against hemagglutinin, a protein that attacks healthy cells. To replace the traditional dead viruses, scientists from UNL have chosen adenoviruses, which provoke the appearance of a cold. Selected adenoviruses have been modified. They were instilled with the “ability” to transport “centralized antigens” of influenza strains (H1, H2, H3 and H5) into the body. The method is based on the research work of Bette Korber, who, when studying the genome of the human ancestors, determined that the genes of the immunodeficiency virus went to Homo sapiens from the monkey. Scientists from UNL, led by Eric Weaver, decided to synthesize central genes, which are the basis of the influenza virus, in a similar way. “Our idea is that these centralized antigens can form the basis of immunity against influenza. Since they represent all strains equally, they can provide a basis for immunity against all known influenza strains, ”said Weaver Associate Professor. According to researchers, it’s too early to talk about the invention of a panacea for influenza suitable for humans. However, the direction in which subsequent research will be conducted is determined. The main task of scientific research is to find a vaccine with a lifelong effect.