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Scientists have found a connection between Parkinson’s disease and the intestines (3 photos)

Parkinson’s disease is an insidious chronic disease of a neurological nature, which affects people of an older age group. And although humanity has known about it for several millennia, and doctors have been studying the causes of its appearance and development for several centuries, modern medicine still cannot cure this disease, but continues to look for methods to combat it. The essence of the disease is the progressive death of neurons responsible for the production of dopamine. Its insufficient production leads to the destruction of neurons in the cerebral cortex. Such changes in the brain, according to scientists at Johns Hopkins University (USA), occur due to aggregation of incorrectly folded accumulations of alpha-synuclein protein (they are also called Levy bodies). This deviation from the norm, based on the observations of scientists on laboratory animals, occurs in the intestine, and then these “substandard” proteins enter the brain. In the early 2000s, this hypothesis was already voiced by the German scientist Heiko Braak, but there was no exact confirmation of it. In 2014, a group of researchers at J. Hopkins University conducted a series of experiments on rats and found that Levy bodies actually spread from the intestines to the brain, which causes pathological signs of Parkinson’s disease. During the experiments, the researchers introduced synthetic improperly folded alpha synuclein into the intestines of healthy mice, and then these animals were monitored for 10 months. Studies have shown that alpha synuclein first aggregates at the junction of the vagus nerve with the intestines, and then spreads through the brain. At the same time, if the vagus nerve was broken, the movement of alpha-synuclein proteins into the brain ceased.As a result of research by scientists, another source of the occurrence of Parkinson’s disease was studied, which means that doctors have to develop ways to block the disease even at the stage of the onset of pathology and prevent the development of this disease.

Sam Richards

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